By Columbia University Irving Medical Center –
A new study reveals how stem cell niche generation is regulated in bone marrow, which could lead to improvements in stem cell transplantation for the treatment of blood diseases.
Bone marrow transplants give patients new blood stem cells to replace original diseased cells and have helped millions of people with blood disorders, including cancer.
Read the paper:
“Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program(link is external and opens in a new window)” was published online April 23 in Cell.
But for about one in every 10 patients, the introduced cells never take hold in the patient’s bone marrow, leaving patients open to severe infections and bleeding events that are often fatal.