NEWS and OPINIONS
Understanding the Risk of Second Cancers After CAR T-Cell Therapy
By The National Cancer Institute - In November 2023, the Food and Drug Administration announced that it was investigating more than 20 instances of second cancers—specifically, T-cell lymphomas—in people who had been treated with CAR T-cell therapies. In several...
Astrocytes Are a Key Player in the Awakeneing of Dormant Neural Stem Cells
By Technology Networks - Research offers new hope for treating neurodevelopmental disorders by activating dormant neural stem cells. Scientists from Duke-NUS Medical School and the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) have...
UofL cardiologist leading clinical trial for high potential new therapy for heart failure
By University of Louisville School of Medicine - A new stem cell therapy for heart failure is being tested in patients at the University of Louisville and UofL Health. The trial is the first in the U.S. to test umbilical cord-derived stem cells in patients for heart...
Next-generation CRISPR-based gene-editing therapies tested in clinical trials
By Natalie Healey - Nature Medicine Going from the laboratory to an approved therapy in 11 years is no mean feat. That is the story of the world’s first approved CRISPR–Cas9 therapy, greenlit by the US Food and Drug Administration in December 2023....
First Engineered T Cell Therapy for Solid Tumors Approved by the FDA
By Inside Precision Medicine - The immunotherapy afamitresgene autoleucel (afami-cel) for the treatment of adults with the rare soft tissue cancer called synovial sarcoma was granted accelerated approval late last week by the U.S. Food and Drug Administration (FDA)....
Researchers decipher new molecular mechanisms related to biological tissue regeneration
By University of Barcelona - A study published in The EMBO Journal opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses on tumour necrosis factor-α (TNF-α) and its receptors TNFR, molecules...
Rapid Stem Cell Model Advances Parkinson’s Research
By Neuroscience News - Researchers have developed a model that quickly converts stem cells to brain cells with Parkinson’s disease (PD) protein structures, allowing for personalized study and treatment. This new approach can transform stem cells into brain cells...
Breaking the Chains: How CRISPR Gene Therapy Gave Victoria Gray a New Life
by Molly Coddington - Technology Networks - Like many young girls in elementary school, Victoria Gray wanted to be a cheerleader, until she was told by her doctor that this simply wouldn’t be possible; the exertion placed on her body by the training regimen could have...
Detecting pancreatic cancer through changes in body composition and metabolism
by Marla Broadfoot, Ph.D. - Mayo Clinic - Pancreatic cancer is a formidable disease, often diagnosed too late for effective treatment. However, new research from Mayo Clinic represents a promising step toward identifying biological signals or biomarkers that may aid...
Cell donors are essential for new therapies. They need to be taken care of
By Priya Baraniak - STAT News - Cutting-edge FDA-approved therapies made from human cells are now being used to treat cancer, diabetes, and other diseases. Currently, most approved cell-based therapies use an individual’s own cells, but the next generation of these...
New study shows ‘dancing molecules’ can regenerate cartilage in 3 days
By Medical Xpress News - In November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving "dancing molecules," to repair tissues and reverse paralysis after severe spinal cord injuries. Now, the same research...
DA Grants Regenerative Medicine Advanced Therapy Designation for AIC100 to Treat Thyroid Cancer
By Kennedy Ferruggia - Pharmacy Times - The FDA has granted regenerative medicine advanced therapy (RMAT) designation for AIC100 (Affylmmune Therapeutics), an ICAM-1 targeting and affinity-tuned LFA-1 binder chimeric antigen receptor (CAR) T-cell therapy product...