by Arkadi Mazin – Lifespan Research Institute –
This may have effects on a significant component of Alzheimer’s.
Scientists have shown that aberrant metabolism of glycogen in neurons is linked to the accumulation of harmful tau protein. Caloric restriction, genetic interventions, and small molecules might help.
Glycogen and the brain
Aberrant aggregation of microtubule-associated protein tau (MAPT), or simply tau protein, is a hallmark of several neurodegenerative diseases [2]. The most famous of them is Alzheimer’s disease, in which tau accumulation in the form of hyperphosphorylated neurofibrillary tangles (NFTs) damages neurons.
