By Stem Cells Translational Medicine –
Mesenchymal stem cells (MSCs) hold tremendous potential for regenerative medicine and the treatment of currently incurable diseases. These adult multipotent progenitor cells are essential for tissue regeneration and wound repair due to their high capacity to differentiate into various tissues. Through paracrine effects, MSCs can regulate immune responses, enhance neovascularization, and improve cell survival. Moreover, MSCs have the ability to preferentially home to damaged tissues and serve as a reservoir of growth and proregenerative factors. Therefore, understanding and enhancing MSC homing efficiency at injury sites is crucial to maximizing their therapeutic effects. In this review, we analyze a variety of strategies to optimize MSC homing and foster the potential of MSC-based cell therapies in regenerative medicine.
