By Mary Ann Liebert, Inc Publishers –
This cover illustrates the original research report submitted by Anastasia Khvorova of the RNA Therapeutics Institute, University of Massachusetts Chan Medical School. This gorgeous image depicts the observation that nuclear clusters of mutant huntingtin mRNA are resistant to RNAi based silencing. This clustering is responsible for the observed discrepancy between levels of protein and mRNA silencing. This is another key investigation from the laboratory of Anastasia Khvorova, to develop our understanding of the relationship between huntingtin RNA and protein levels where it matters functionally. The cover art was designed by first author, Sarah Allen, and created by lab mate, Theodore C..
– Graham Parker – Editor in Chief
