UK scientists have begun the first clinical trial of lab-grown red blood cells, with the hope that they survive longer in volunteers than donated blood cells.
By Ed Cara – Gizmodo
An important clinical trial is now underway in the UK. The study is the first to transfuse red blood cells grown in the lab from donated stem cells into humans. Should this research pay off, these blood cells would be incredibly valuable for people with rare blood types, though they wouldn’t replace the need for traditional blood donation.
The RESTORE trial, as it’s known, is being conducted by scientists from the UK’s National Health Services and various universities. At least 10 healthy volunteers are expected to be enrolled in the study. All of them will receive two mini-transfusions, spaced four months apart and in random order, of the lab-grown blood cells and standard cells, both of which are derived from the same donor. As of early Monday, two participants have already gotten the lab-grown blood cells and so far appear to have experienced no side-effects.
The first-of-its-kind experiment is a Phase I trial, meaning that it’s primarily designed to test the safety of a novel or experimental treatment. But the lab-grown cells are theoretically fresher than the mix of newer and older blood cells taken from a typical blood donation (on average, red blood cells live for about 120 days). So the researchers are hoping that the lab-grown cells survive longer than the standard cells in their recipients.