By Tohoku University –
Stem cells possess the unique ability to self-renew and transform into different types of cells. For example, rare hematopoietic stem cells found in bone marrow can become any type of blood cell. Throughout life, they can produce new blood cells to replace those lost because of infection, bleeding, or chemotherapy.
However, as people and animals age, hematopoietic stem cells become less effective. Their numbers increase, but their ability to rebuild the blood system declines. These changes may contribute to anemia, reduced immunity, blood clots, and age-related blood disorders. Researchers at Tohoku University used AI to predict which genes may lead to aging in stem cells, and subsequently tested these candidates in animal studies. This research provides a clearer molecular framework for understanding why blood production becomes unbalanced with age, shining light on an issue that affects everyone as they grow older.
