By Susan Buckles – Mayo Clinic
A dissolvable plug delivered stem cell therapy with few side effects in patients with single tract perianal fistulas, Mayo Clinic researchers discovered. Perianal fistulas are painful tunnels between the intestine and the skin that often do not go away with standard medical or surgical care. People with Crohn’s disease or other inflammatory bowel conditions are most at risk for this condition.
In a prospective, phase 1 clinical trial, researchers loaded stem cells from a patient’s own fat tissue onto a bioabsorbable plug that was then surgically implanted to close the anal fistula tract. They followed the patients for one year and reported results of their early research in Diseases of the Colon & Rectum.