CAR T Cells Derived From Stem Cells Open Door To Universal Donor Cell Lines

Jul 17, 2023

by William A. Haseltine – Forbes

Induced pluripotent stem cells (iPSC), a continuing muse in cell therapy research, could potentially be used to improve flaws associated with conventional CAR T therapy.

What if an effective cancer treatment became cheaper and easier to produce? One study published in the journal Nature Biomedical Engineering builds on this vision to improve medical innovation CAR T therapy by using stem cells and extensive gene editing. The results demonstrate that the experimental CAR T cells—derived from stem cell donors instead of patients—can be used to effectively treat mice models of cancer. Looking forward, clinical translation of this model could lower the cost, time and labor barriers which make CAR T therapy prohibitive for most.

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