Scientists Identify How a Biological Pathway Leads Stem Cells to Die or Regenerate

Jan 25, 2023

Manipulating Cell Signaling Can Possibly Ensure the Body Has a Healthy Amount of Cells

By Stephanie Cajigal – Cedars Sinai

A new study led by Cedars-Sinai and the University of California, San Francisco (UCSF), has determined that altering a cellular process can lead stem cells—cells from which other cells in the body develop—to die or regenerate.

The findings, published in the peer-reviewed journal Cell Stem Cell, may assist in the development of new drugs that can manipulate this process to slow or stop cancer from growing and spreading, and enable regeneration in the context of other diseases.

Ophir Klein, MD, PhD, executive director of Cedars-Sinai Guerin Children’s and the senior author of the study, said the findings underscore the body’s need to produce just the right amount of new cells.

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